Upside uses a combination of a proprietary, specially-designed culture chamber with methods for speeding cellular growth to achieve its superior product. The skin is grown on a mesh that confers superior handling.

The process for culturing our engineered skin product is as follows:

  • Digest cells from a sample of skin
  • Culture cells in flasks
  • Transfer skin cells from flasks to Upside's culture chambers
  • Seal chambers
  • Cells attach to coated synthetic mesh held on frame
  • Incubate
  • Turn over chambers
  • Frame holding mesh and cells falls to bottom
  • Cells are now next to a gas permeable membrane
  • Gas passing through membrane gives signal for epithelial cells to differentiate
  • Incubate
  • Skin ready to be transported to patient in same chambers